Some of you will be up or down 50+ points after tonight, so good luck with that.
It's unusual for a prime-time contest to feature two top-tier QBs and three top-tier WRs, not to mention 3-4 potentially startable RBs and another couple likely startable WRs. Add in the fact that both teams have defensive deficiencies, and we're looking at quite an evening.
On that defensive side, Seattle has been atrocious against the pass. There's no other way to say it. They gave up 397 air yards to Cam Newton, which were the most Cam's had since his first two NFL games in 2011. Against the run they've given up only 3.7 yards per carry, but also 14 rushing TDs--third most in the league. Opponents aren't running much on them, in part, because it's easier to take advantage of their secondary. Christian Kirk (expert consensus 27th-ranked Week 11 WR) should be viewed as a very high-upside WR2+, while TE Dan Arnold (7+ points in three of his last four games) is a terrific dart throw for TE-needy managers.
The ground game appears to be more set in stone than we saw earlier this season. Kenyan Drake looked good in his return last weekend and will be the higher-volume 1A while Chris Edmonds assumes a complementary role. If Seattle somehow jumps out early, of course we could see Edmonds getting more touches. If you believe in Drake, you have to start him. If you don't believe in him, well, you have a point: He's a slow start away from Edmonds taking over. But playing the percentages, Drake and Edmonds are realistic 8+ point options with decent breakout potential.
If you want to hear about DeAndre Hopkins, there are plenty of other sites to read. He's arguably the biggest no-brainer start of the week. (And if he gets hurt on the first play, that wasn't me who jinxed him.)
Meanwhile, Arizona is a bit stronger in the passing game, and on the ground they're yielding a more potent 4.5 YPC, but only six rushing scores. With Chris Carson reportedly doubtful to suit up, Carlos Hyde and Alex Collins could be in for a couple hot-hand / cold-hand performances. Surprisingly, I prefer Collins over the 30-year-old Hyde. I simply don't like Hyde's ceiling as a post-prime, largely TD-dependent back. Both he and Collins have lower ceilings than their Cardinal counterparts, meaning Hyde and Collins are riskier streamers.
The biggest question mark is Tyler Lockett, who's expected to play in a must-win game between these two 6-3 teams. Lockett is the classic "Do you risk an early-game re-injury in exchange for the strong possibility of WR1 production?" You know your team better than I do, so you know how much risk you're willing to take. If Lockett's starting, that would be good enough for me unless I had a top-16 WR on my bench to plug in Sunday or Monday. You also don't need my (previously errant) thoughts on D.K. Metcalf, who seemingly has to start on every fantasy team given his uber-high potential. And as mentioned the other day, David Moore is fully streamable if Lockett sits or is less than 100%. He is both exceptionally risky and also possibly the highest-upside WR available on your waivers depending on Lockett's condition.
Mired in a two-game losing stream, Seattle will come out on top. I wouldn't be surprised if Russell Wilson cracks an insane 400/5 line, while nothing's preventing Kyler Murray from hitting 350/4.
And if the game ends 9-6, I'll fold this page and try fantasy golf.