Question: To what extent do missed games impact players' overall production?
Answer: A lot.
Explanation: Sometimes the difference between RB1 and RB2 production, or WR2 and WR3 output, is who plays more games.
Why This Matters: This is why per-game production is an underrated stat, particularly in shallower leagues where great value can be found on waivers if a starter gets hurt. The fact is, most managers would prefer to have an RB1 who plays only eight games, gets hurt, and then plummets into RB3 territory for the season due to being sidelined . . . rather than a back-end RB2 who plays all 16 games.